Department of Biological Science,Graduate School of Science, Hiroshima University

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Animal Science Developmental Biology
Cell Biology
Molecular and Cellular Physiology
Plant Biology Plant Taxonomy and Ecology
Plant Molecular Physiology
Plant Molecular Biology and Bioinformatics
A new laboratory
Diversity Biology Marine Molecular Biology Marine Biological Laboratory
Island Biology Miyajima Natural Botanical Garden
Amphibian Biology Evolutionary Developmental Genomics Amphibian Research Center
Organ Regeneration Mechanisms
Evolution and Diversity
Regulatory Signals for Development/Regeneration
Plant Genetic Resources Plant Genetic Resources Laboratory of Plant Chromosome and Gene Stock

Animal Science Course

Developmental Biology

Staff/KIKUCHI Yutaka (Professor), TAKAHASHI Haruko (Assistant Professor)

The major interest of our laboratory is to clarify the molecular mechanisms of cell fate determination during development and regeneration. For this purpose, we have been focused on two major research projects: (1) studies on the mechanisms of differentiation, trans-differentiation, and dedifferentiation using zebrafish and cell culture system, (2) studies on the mechanisms of transcriptional regulation by chromosomal dynamics.

Key Words Cell fate, Dedifferentiation, Regeneration, Transcriptional regulation

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Cell Biology

Staff/CHIHARA Takahiro(Professor), HAMAO Kozue (Associate Professor), OKUMURA Misako (Associate Professor)

Our research goal is to reveal how cell society is constructed and maintained during animal development, growth and aging. To this purpose, we are studying the molecular mechanisms of cytokinesis, cell patterning, cell-cell interaction, and the impact of aging on cells/organisms by using sophisticated Drosophila genetic methods, and molecular and biochemical methods with mammalian cell culture system.

Key Words Nervous system, Cytokinesis, Cell patterning, Cell-cell interaction, Aging

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Molecular and Cellular Physiology

Staff/IMAMURA Takuya (Professor), UEKI Tatsuya (Associate Professor), MORISHITA Fumihiro (Assistant Professor)

We are studying the brain/nervous system and essential trace elements,that are among the main themes of animal physiology. Recently, we havesucceeded in making a database of promoter-associated non-coding RNA(pancRNA), a group of functional non-coding RNAs, by employing technologies of big data analyses for human and primate brains. We are currently working to elucidate the biological significance of primate-specific non-coding RNA that can be involved in the epigenetic mechanism of neural networking using single-cell level analysis of human brain organoids. Marine animals also have many advantages asresearch materials for physiology, and we are conducting the studieson identification of neuropeptides and related enzymes and the mechanism of their action using Aplysia, and the those on metal accumulation and utilization, and adhesion mechanism, using sea squirts.

Key Words Brain, neural stem cells, non-coding RNA, single cell level analysis, neuropeptides, amidases, transition metals, redox, electron transport chain

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Plant Biology Course

Plant Taxonomy and Ecology

Staff/YAMAGUCHI Tomio (Professor), SHIMAMURA Masaki (Associate Professor)

Research in this laboratory concerns taxonomy, phylogeny, morphology and ecology on nonvascular plants including bryophytes, freshwater algae, lichens, and others. The department maintains a research Herbarium (HIRO) which has an extensive bryophyte collection.

Key Words Bryophytes, Cryptogams, Taxonomy, Ecology, Anatomy, Cell biology, Molecular phylogeny

Plant Molecular Physiology

Staff/FUKAZAWA Jutarou (Assistant Professor)

This laboratory has focused on the molecular mechanism of cell responses to environmental changes. Our research projects are (1) regulatory mechanisms of gibberellin biosynthesis and signaling, (2) response mechanisms to the environmental stimuli.

Key Words Plant hormone, Transcriptional regulation, Signal transduction, Kinase, Protein-protein interaction

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Plant Molecular Biology and Bioinformatics

Staff/MORIGUCHI Kazuki (Lecturer)

Suppose cells obtain genes from entirely different organisms, they can develop new functions rapidly. We focus on phenomena of active gene transfer from bacteria domain to eukarya domain, i.e. T-DNA transport to plants by phytopathogenic agrobacteria, and plasmid DNA mobilization to yeasts by some proteobacteria.

Key Words Horizontal gene transfer, Plasmid DNA, Conjugation, Bacteria, Eukaryotes

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A new labortatory

Staff/HIRAKAWA Yuki (Professor)

in preparation

Key Words in preparation

Web page: in preparation

Diversity Biology Course

Marine Molecular Biology

Staff/TAGAWA Kunifumi (Associate Professor), ARIMOTO Asuka (Assistant Professor)

We conduct “Evo-Devo (Evolution and Development)” research in Mukaishima island, Onomichi City, that is located in the “Shimanami Kaido” where is rich in the diversity of marine organisms. Specifically, we study on the origin and evolution of deuterostomes and bilaterians by analyzing comparative developmental biologly and comparative genomics of marine animals such as Ptychodera flava, a species of Hemichordata that is most ancestral deuterostomes and Praesagittifera naikaiensis, a species of Acoelmorph that is most ancestral bilaterian which includes most animals.

Key Words Marine organisms, diversity, Evo-Devo, acorn worm, acoelworm, Origin and evolution of detuerostomes and bilaterians

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Island Biology (Miyajima Natural Botanical Garden)

Staff/TSUBOTA Hiromi (Associate Professor)

The Miyajima Natural Botanical Garden is situated along the north coast of Miyajima (Itsukushima) Island, southwestern Japan, ca. 20 km southwest of Hiroshima City. The island is famous as a UNESCO World Heritage Site, and is covered with natural forest and maritime vegetation. Our research projects are island biology, phytogeography, ecology, and conservation biology, utilizing the excellent natural resources of Miyajima Island.

Key Words Island biology, Biodiversity, Phytogeography, Phytosociology, Ecology, Molecular phylogenetics, Cryptogamic botany

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Amphibian Biology Course

Evolutionary Developmental Genomics (Amphibian Research Center)

Staff/OGINO Hajime (Professor), IGAWA Takeshi (Associate Professor), SUZUKI Makoto (Assistant Professor)

We are studying the molecular mechanisms of genome evolution and environmental adaptation in chordates through comparative functional analysis of developmental regulatory genes using frogs with various ecologies and amphioxus, which are called "living fossils. We also use transgenesis and genome editing technologies to create useful genetically modified clawed frogs, which we use to study genomic and epigenomic regulation of development and regeneration of organs (eye, brain, spinal cord, etc.) and pathogenesis of genetic diseases.

Key Words Genome evolution, development, regeneration, environmental adaptation, transcriptional regulation, epigenetics, clawed frogs, wild species

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Organ Regeneration Mechanisms (Amphibian Research Center)

Staff/HAYASHI Toshinori (Professor), OKAMOTO Kazuko (Assistant Professor)

We are studying the mechanism of organ regeneration in terms of cell proliferation, differentiation, and metabolism, using the Iberian ribbed newts as a model animal. We are also conducting research to develop the newt as a bioresource.

Key Words Iberian ribbed newt, organ regeneration, cell cycle regulation, metabolism, bioimaging

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Metamorphosis (Amphibian Research Center)

Staff/NAKAJIMA Keisuke (Assistant Professor), TAZAWA Ichiro (Assistant Professor)

We study the mechanism of metamorphosis, found in many lineages of the animal kingdom, and its evolution using amphibians as a model. Our approach uses a wide range of techniques, from classical histology to advanced genome editing.

Key Words Metamorphosis, morphology, development, evolution, frogs, newts, model organisms, non-model organisms

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Evolution and Diversity (Amphibian Research Center)

Staff/MIURA Ikuo (Professor, Special Designation), HANADA Hideki (Assistant Professor)

We engage in pioneering research to reveal the processes and mechanisms mediating diversity, and we strive to maintain and preserve diversity across a wide range of biological hierarchies at the gene–genome–chromosome, cell–tissue, individual, population, species, and higher taxonomic levels. Particulary focussing on sex and evolution in amphibians. Also we study the effects of chemical substanes on amphibians.

Key Words Evolution, Diversity, Phylogenetic System, Sex and Reproduction, Ecology, Preservation, Genome Biology, and Effects of chemical substances

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Regulatory Signals for Development/Regeneration (Amphibian Research Center)

Staff/SUZUKI Atsushi (Associate Professor)

We are studying the molecular mechanisms of vertebrate early development, maintenance/differentiation of stem cells, and tissue regeneration. We focus on the roles of inducing factors and downstream cell signaling factors.

Key Words Early development, Stem cell, Tissue regeneration, Inducing factor signal

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Plant Genetic Resources Course

Plant Genetic Resources (Laboratory of Plant Chromosome and Gene Stock)

Staff/KUSABA Makoto (Professor), TOYOKURA Koichi (Assistant Professor), NOBUSAWA Takeshi (Assistant Professor)

We are conserving various Chrysanthemum and cycad species and developing the model species/line of the genus Chrysanthemum. In addition, mutants of the model plant species are isolated and used for the molecular genetic research.

Key Words Genetic resource, Chrysanthemum, Cycad, Model plant, Mutant, Gene function analysis

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Affiliated Facilities

Marine Biological Laboratory

2445 Mukaishima-cho, Onomichi-shi, Hiroshima,

Miyajima Natural Botanical Garden

Amphibian Research Center

Laboratory of Plant Chromosome and Gene Stock

1-4-3 Kagamiyama, Higashi-Hiroshima-shi, 739-8526