- 追加された行はこの色です。
- 削除された行はこの色です。
#author("2024-03-27T07:16:47+00:00","","")
*Masanobu Obara, Ph.D. [#da05421f]
#author("2024-04-02T07:27:58+00:00","default:jos","jos")
*旧スタッフ紹介 [#s11fe4c0]
Professor, Laboratory of Molecular and Cellular Physiology
Hiroshima University
**小原 政信（おばら まさのぶ）教授
昭和29年鹿児島県霧島市生まれ。昭和54年九州大学大学院理学研究科博士課程前期修了（理学修士）。昭和59年理学博士（九州大学）。東京大学医科学研究所(癌生物学部門)・助手、科学技術庁基礎科学研究員（理化学研究所筑波センター真核細胞研究室）、科学技術振興事業団プロジェクト研究員を経て平成6年広島大学理学部助教授。平成12年理学研究科生物科学専攻助教授（重点化による）。平成23年理学研究科生物科学専攻教授。現在、細胞外マトリックス分子、特にフィブロネクチンの生理機能の解明、胚発生における酸素の生理機能の解明、がん細胞の転移における間葉系細胞の役割の解明を目指して研究を実施中。この間、アメリカ国立がん研究所分子生物学部門博士研究員(Dr KM Yamada)、台湾Chang Gung大学病院（肝臓移植外科）、広島大学医学部及び岡山大学医学部非常勤講師を勤めた。昭和59年産業医科大学会長賞を受賞。2020年3月、定年退職。
Kagamiyama 1-3-1, Higashihiroshima 739-8546, Hiroshima, Japan
**道端 齊（みちばた ひとし）教授
昭和22年石川県輪島市生まれ。昭和46年新潟大学理学部生物学科卒業、昭和51年東京大学大学院理学系研究科動物学専門課程博士課程修了(理学博士)。富山大学理学部助教授を経て平成3年広島大学理学部附属臨海実験所助教授、翌年同教授。平成15年9月より理学研究科生物科学専攻教授。この間、日本学術振興会ナポリ臨海実験所派遣研究員、米国ブランダイス大学化学教室博士研究員を勤めた。約30年前からホヤのバナジウム濃縮機構の研究を開始し、一連の仕事で平成7年度日本動物学会賞と井上学術賞を受賞した。2001年から国際バナジウムシンポジウム組織委員。2012年3月定年退職。2012年4月、広島大学名誉教授。
E-mail: &ref(e-mail-obara.jpg);
ReaD & Researchmap : http://researchmap.jp/read0017006
**松島 治（まつしま おさむ）教授
現、広島工業大学 環境学部 地球環境学科 教授
Ph.D. degree from Kyushu University in 1984, Research Associate in University of Occupational and Environmental Health (1979-1985), Visiting Fellow in National Cancer Institute (LMB/DCBD, Dr. KM Yamada, 1985-1988), Assistant Professor in The Institute for Medical Science, Tokyo University (1988-1991), Special Basic Science Researcher, RIKEN (1991-1993), Research Scientist, ERATO, JST (1993-1994), Associate Professor (1994-2011), and Professor in Hiroshima University (2011-Present).
ReaD & Researchmap : http://researchmap.jp/read0016981/
**古川 康雄（ふるかわ やすお）助教授
広島大学 統合生命科学研究科・総合科学部 教授。2024年3月、定年退職。
***Research Interest: [#kc05d1f9]
ReaD & Researchmap : http://researchmap.jp/read0046112/
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現スタッフの紹介は[[こちら>スタッフ]]です。
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1) Fibronectin and Integrin interaction in development, wound healing, and tumor metastasis
2) Physiological role of oxygen in brain during normal development and diseases
***Publications: [#na6b9480]
1) Obara M., Sakuma, T., Fujikawa, K. The third type III module of human fibronectin mediates cell adhesion and migration. Journal of Biochemistry,47, 327-335, 2010 （Impact factor(IF):1.945, Citation frequency (CF):3）
2) Adachi, T., Wang, X., Murata, T., Obara, M. Akutsu, H., Machida, M., Umezawa, A.,Tomita, M. Production of a non-helical collagen a chain in transgenic silkworms and its evaluation as a gelatin substitute for cell culture., Biotechnology and Bioengineering, 106, 860-870, 2010 (IF:3.377, CF:4)
3) Chen W, Obara M, Ishida Y, Suzuki K, Yoshizato K. Characterization of histone lysine-specific demethylase in relation to thyroid hormone-regulated anuran metamorphosis.Development Growth and Differrentiation. 49(4) :325-334, 2007 (IF:2.28, CF:0)
4) Xi Y, Obara M, Ikeda S, Yoshizato K. Gene expression and tissue distribution of cytoglobin and myoglobin in the Amphibian and Reptilia Gene. 2007, 15; 398, 94-102、2007(IF:2.416, CF:9)
5) Ogawa T, Tateno C, Asahina K, Fujii H, Kawada N, Obara M, Yoshizato K. Identification of vitamin A-free cells in a stellate cell enriched fraction of normal rat liver as myofibroblasts Histochemistry Cell Biology, 127,161-174, 2007 (IF;3.021, CF;10)
6) Y Tateaki, T Ogawa, N Kawada, T Kohashi, K Arihiro, C Tateno, M Obara, K Yoshizato. Typing of hepatic nonparenchymal cells using fibulin-2, and cytoglobin/STAP as liver fibrogenesis-related markers. Histochemistry and Cell Biology, 122, 41-49, 2004 (IF:3.021, CF:26)
7) Y Ishida, K Suzuki, R Utoh, M Obara, K Yoshizato. Molecular identification of the skin tranformation center of anuran larval skin using genes of rana ketatin and secreted protein acidic and rich in cysteine as probes.Development, Growth and Differentiation, 45, 515-526, 2003 (IF:2.28, CF:9)
8) K Oofusa, O Tooi, A kashiwagi, K Kashiwagi, Y Kondo, M Obara, K Yoshizato. Metal ion-responsive transgenic Xenopus laevis as an environmental monitoring animal. Environmental Toxicology and Pharmacology, 13, 153-159, 2003 (IF:1.293, CF:3)
9) T. Kato, K Miyazaki, K Nishikawa, K Koshiba, M Obara, K Yoshizato. Unique expression patterns of matrix metalloproteinases in regenerating newt limbs. Developmental Dynamics, 226, 336-376. 2002(IF3.083, CF:23)
10) Y Watanabe, R Tanaka, H kobayashi, R Utoh, K Suzuki, M Obara, K Yoshizato. Metamorphosis dependent transcriptional regulation of xak-c, a novel Xenopus type I keratin gene. Developmental Dynamics, 225, 561-570. 2002(IF:3.083, CF:16)
11) K Asahina, N Kawada, DR Kristensen, K Nakatani, S Seki, M Shiokawa, C Tateno, M Obara, K Yoshizato. Characterization of human stellate cell activation-associated protein (STAP) and its expression in human liver Biochmica Biophysica Acta, 1577, 471-475. 2002(IF:4.374, CF:21)
12) Suzuki, R Utoh, K Kotani, M Obara, K Yoshizato. Lineage of anuran epidermal basal cells and their differentiation potential in relation to metamorphic skin remodeling. Development, Growth and Differentiation, 44, 225-238. 2002 (IF:2.28, CF:20)
13) T Kohashi, U Tateaki, C Tateno, T Asahara, M Obara, K Yoshizato. Expression of pleiotropin in hepatic nonparenchymal cells and preneoplastic nodules in carbon tetrachloride-induced fibrotic rat liver.Growth factors, 20, 53-60. 2002 (IF:2.468, CF:7)
14) Nakano, T Hara, T Hayama, M Obara, K Yoshizato, K Oohama. Membrane type I matrix metalloproteinase is induced in decudual stroma without direct invasion by tropoblasts.Molecular Human Reproduction, 7, 271-277. 2001 (IF:3.005, CF:7)
15) R Utoh, K Asahina, K Suzuki, K Kotani, M Obara, K Yoshizato. Developmentally and regionally regulated participation of epidermal cells in the formation of collagne lamella of anuran tadpole skin.Development, Growth and Differentiation, 42, 571-580, 2000 (IF:2.28, CF:14)
16) Oomizu, F Sahuc, M Inamatsu, T Matsuzaki, K Asahina, M Sasaki, M Obara, K Yoshizato. Kdaf, a novel gene associated with the strafication of the epithelium. Gene, 256, 19-27, 2000 (IF:2.416, CF:18)
17) K.Asahina, M. Obara, K.Yoshizato. Expression of genes of type I and II collagen in the formation and development of blastema of regenerating newt limb. Developmental Dynamics, 216, 59-71. 1999 (IF:3.083, CF:8)
18) K.Asahina, E Utoh, M. Obara, K. Yoshizato. Cell-type specific and thyroid hormone-dependent expression of genes of a1(I) and a2(I) collagen in intestine during amphibian metamorphosis. Matrix Biology, 18, 89-103.1999 (IF:3.558, CF:14)
19) Y. Yokasaki, N. Matsuura, S. Higashiyama, I. Murakami, M. Obara, M. Yamakido, N. Shigeto, J, C.D. Sheppard. Identification of the ligand binding site for the integrin a9b1 in the third fibronectin type III repeat of tenascin-C.Journal of Biological Chemistry, 273, 11423-11428.1999 (IF:5.328, CF:89)
20) K Yoshizato, M Tsukahara, T Oki, M Obara. The interaction of cellular fibronectin with collagen during fibroblast-mediated contraction of collagen gels. Journal of Investigative Dermatology Symposium Proceedings, 4, 190-195, 1999
21) M Obara, K Yoshizato. Vector-swapping strategy with an exonuclease in cloning and high expression of small PCR products. Bio-Techniques, 24, 44-46.1998 (IF:2.548, CF:0)
22) K. Asahina, K. Oofusa, M. Obara, K. Yoshizato. Cloning and characterization of the full-length cDNA encoding a2 type I collagen of bullfrog Rana catesbeiana. Gene, 194, 283-289. 1997(IF:2.416, CF:17)
23) M. Obara, K. Yoshizato. A novel domain of fibronectin revealed by epitope mapping of a monoclonal antibody which inhibits fibroblasts-mediated collagen gel contraction. FEBS Letters, 412, 48-52. 1997 (IF:3.541, CF:12)
24) M. Mukai, M. Obara, K. Yoshizato. Characterization of gene of anuran cathepsin D as metamorphosis-regulating enzyme. Development, Growth and Differentiation, 37,463-478, 1995 (IF:2.28, CF:10)
25) M. Obara, K. Yoshizato. Possible Involvement of the a5 subunit of a5b1 integrin with the synergistic region of the central cell-binding domain of fibronectin in cells to fibronectin binding. Experimental Cell Research, 216, 273-276. 1995 (IF:3.589, CF:13)
26) H. Kawakatsu, R. Shiurba, M. Obara, H. Hiraiwa, K. Kusakabe, T. Sakakura. Human carcinoma cell synthesize and secrete tenascin in vitro. Japan Journal of Cancer Research (currently Cancer Science), 83,1073-1080. 1995 (IF:3.771, CF:47)
27) RD. Bouditch, CE. Halloran, S. Aota, M. Obara, EF. Plow, KM. Yamada, MH. Ginsberg. Integrin aIIbb3 (platelet GPIIb-IIIa) recognizes multiple site in fibronectin. Journal of Biological Chemistry, 266, 23323 23328. 1991 (IF:5.328, CF:95)
28) M. Yamagata, KM. Yamada, S.S. Yamada, Shinomura, H. Tanaka, N. Nishida, M. Obara, K. Kimata. The complete primary structures of the typeXII collagen show a chimeric molecule with reiterated fibronectin type III motif, von Willbrand factor A motifs, a domain homologous to a noncollagenous region of type IX collagen, and short collagenous domain with an Arg-Gly Asp site. Journal of Cell Biology, 115, 209-221. 1991 (IF:9.575, CF:96)
29) M. Ichinose, K. Miki, M. Tatematsu, C. Furihata, M. Matsushima, Y. Ichinose, M. Tanji, T. Konishi, M. Obara, H. Inose, K. Kuroiwa, T.Takahashi, T. Kageyama, Y. Takahashi. Hydrocortisone-induced enhancement of expression and changes in methylation of pepsinogen gene in stomach mucosa of the developing rat. Biochemical and Biophysical Research Communications, 172, 1086-1093.1990(IF:2.548, CF:15)
30) M.J. Humphries, M. Obara, K. Olden, KM. Yamada. Role of fibronectin in adhesion, migration and metastasis. Cancer Investigation, 7, 373-393. 1989 (IF:2.105, CF:72)
31) Nagata, K. Hirayashi, A.Nakai, S. Saga, M. Obara, K.M. Yamada. A novel transformation sensitive heat shock protein (HSP 47). Hyperthermic Oncology, 2, 252-255. 1988
32) S.Dufour, J-L. Duband, M.J. Humphries, M. Obara, K.M. Yamada, J.P. Thiery. Attachment, spreading, and locomotion of avian neural crest cells are mediated by multiple adhesion site on fibronectin molecules. EMBO Journal, 4,2661 2671. 1988 (IF:8.993, CF:178)
33) K. Nagata, K. Hirayashi, M. Obara, S. Saga, K.M. Yamada. Biosynthesis of a novel transformation-sensitive heat shock protein that binds to collagen. Journal of Biological Chemistry, 263, 8344-8349.1988 (IF:5.328, CF:49)
34) M. Obara, M.S. Kang, K.M. Yamada. Site-directed mutagenesis of the cell binding domain of human fibronectin: Separable, synergistic sites mediate adhesive function. Cell, 53, 649-657.1988 (IF:31.152, CF:327)
35) C. Furihata, M. Obara, T. Matsushima. In vivo short-term assay for identification of organ specific carcinogen and tumor-promoters. Journal of University of Occupational and Environmental Health, 11, 641-651.1988
36) S. Kubomura, M. Obara, Y. Karasaki,H. Taniguchi, S. Gotoh, T. Tsuda, K. Higashi, K.Osato, H.Hirano. Genetic analysis of the cell-binding domain region of the chicken fibronectin gene. Biochimica Biophysica Acta , 910,171-181. 1987 (IF:4.374, CF:11)
37) M. Obara, MS. Kang, S. Dufour, A. Kornblihitt, J.P. Thiery, KM. Yamada. Expression of the cell binding domain of fibronectin in E.coli :Identification of sequences promoting full to minimal adhesive function. FEBS letters, 213, 261-264. 1987 (IF:3.541, CF:35)
38) T. Tsuda, M. Obara, H. Hirano, S. Gotoh, S. Kubomura, K. Higashi, A. Kuroiwa, A. Nakagawara, K. Shimizu, Analysis of N-myc amplification in relation to disease stage and histologic type in neuroblastoma.Cancer, 60, 820-826.1987 (IF:5.418, CF:105)
39) K.Ikeuchi, M. Obara, H. Hirano, S. Gotoh,Y. Karasaki, K. Higashi. Heme metabolism and turnover of cytochrome P 450 in tumor-bearing mouse livers.Journal of University of Occupational and Environmental Health, 7,269-277.1985
40) K. Higashi, K. Ikeuchi, M. Obara, Y. Karasaki, H. Hirano, S. Gotoh, Y. Koga, Purification of a single major form of microsomal cytochrome P-450 from tulip bulbs. Agricultural and Biological Chemistry (currently Bioscience, Biotechnology and Biochemistry) 49, 2399- 2405. 1985 (IF:1.326, CF:37)
41) M Obara. Studies on the ribosomal RNA methylation in the nucleoli from Ehrlich ascites tumor cells.Thesis, Graduate School of Science, Kyushu University, Nov. 29, 1984
42) K. Higashi, K. Ikeuchi, Y. Karasaki, M. Obara, Isolation of immunologically distinct form of cytochrome P-450 from microsome of tulip bulbs. Biochemical and Biophysical Research Communications, 115, 46-52.1983 (IF:2.548, CF:29)
43) M. Obara, K. Higashi, Recognition of the ribosomal RNA structures by purified nucleolar methyltransferase. Journal of University of Occupational and Environmental Health, 5, 337-342,1983
44) M. Obara, H. Hirano, K. Higashi, Purification and characterization of nucleolar ribonucleic acid methylase from Ehrlich ascites tumor cells of mice. Biochemistry, 21, 1374-1380. 1982 (IF:3.226, CF:5)
45) M. Obara, Y. Kuchino, K. Higashi, Isolation of nucleolar methylase producing only 5-methyl-cytidine in ribosomal RNA. Biochemical and Biophysical Research Communications, 104, 241-246, 1982 (2.749) (IF:2.548, CF:5)
46) M. Obara, Y. Karasaki, M. Ohno, a-Chymotrypsin catalyzed hydrolysis of peptide substrates. Effect on the reactivity of the secondary interaction due to the peptide moiety C-terminal to the cleaved bond. Journal of Biochemistry, 86, 461-468, 1979 (IF:1.945, CF:7)